Accra
Accra is etymologically owed to the local Akan word nkran which is the word for all types of ants. It is not known if the Akan, the largest ethnic group in the country were referring to anthills in the area or the name was in reference to the Ga, the main ethnic group that populates modern Accra.
But Accra was founded around the 15th century and gained its significance through its usefulness to the British traders and later, colonizers. It has been the seat of any government in Ghana (Gold Coast, formerly) since 1877.